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Nat Cell Biol 16(11):10691079 Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (2014) Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

These limitations have prompted researchers to explore alternative, non-destructive methods, such as label-free techniques, which offer advantages such as low damage to cells, high sensitivity, and small working volumes (Cunningham & Laing, 2008