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Well, once it became understood that one cause of autism may reside in the synapsesthe so-called soul of the brain, the nerve-to-nerve junctions where information is transmittedattention turned to HSPs, heat shock proteins, released by the brain when you have a fever, that can improve synaptic transmission, and thus, may be capable of improving long-range [brain] connectivity which is depressed in [autism]. ASD stands for autism spectrum disorder