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In addition, in silico analysis of the enzymes involved in the proteolytic, lipolytic, and carbohydrate metabolism pathways was performed, and a diverse enzymatic profile which includes protease activity, production of short-chain fatty acids (SCFA), and free amino acids (FAA) was demonstrated

The synthetic mRNA construct of claim 1, wherein the protein or polypeptide is at least 85%) identical to a portion of a reference protein, wherein the reference protein is human ornithine transcarbamylase (hOTC)

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the gene or transcript to be corrected is in a non-dividing cell