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Compared with the oral calcium salt formulation (bioavailability 12%37%), fosfomycin trometamol achieves serum concentrations 2- to 4-fold greater, establishing it as the preferred oral formulation for treating uncomplicated urinary tract infections (UTIs) (Neuner et al., 2012)

The endoplasmic reticulum (ER) is responsible for lipid biosynthesis in cells, arising as the main source of essential components of membrane bilayers such as phospholipids and cholesterol, which are distributed to different intracellular compartments, including mitochondria

Finally, the membranes were washed with PBST three times, and a ChemiDoc XRS System (Bio-Rad, CA, USA) was used to detect the expression of proteins with an enhanced chemiluminescence (ECL) kit (NCM Biotech, Suzhou, China)

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