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5 cm (55%) and 2 cm (20%) in active and controlled acromegalic patients, respectively [90]

These results are consistent with animal models of CRS in which tumor-infiltrating macrophages have been identified as a major source of IL-6 (32, 33)

It should also be noted that chronic sleep deprivation may lead to more profound deficits in attention, and habitual use of L-theanine and caffeine may result in diminished attentional benefits over time due to the development of tolerance

However, some aspects reported in guidelines are not practical in the daily routine of family physicians but are rather theoretical considerations based on new scientific results