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Its really important to understand what the FDA is doing, who the makeup of the FDA committee members are, what their backgrounds are, what their potential, if any, financial conflicts of interest are, and what their ultimate goals are as individuals and as a committee, because there may be some conflicts with respect to some of these products, Frank said

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If orforglipron receives a more favorable formulary position than competing injectables (due to lower list price, manufacturing scalability, or negotiated rebates), payers may require a trial of orforglipron before approving more expensive injectable alternatives

The sample included all adult patients with schizophrenia (see Supplementary Methods for additional details) who received an antipsychotic prescription between January 1, 2006 and December 31, 2019