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Iraqi J Med Sci

Consequently, neovascularization is insufficient, contributing to poor wound healing in DFUs ( Hypoxia is another hallmark of diabetic wounds, driven by reduced perfusion due to peripheral vascular disease and hyperglycemia-induced mitochondrial dysfunction

Additionally, the downstream signaling pathways of glutamate receptors, including cAMP, AC, MAPK, and CaMKII, converge on CREB (cAMP response element-binding protein), a key factor in new protein synthesis required for memory formation [112]