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To unravel the metabolic modifications associated with the onset of obesity and diabetes, we conducted metabolomic and transcriptomic analyses on WT and Alms1 -/- mice at three distinct ages: at 6 weeks of age (before the development of AS symptoms), at 10 weeks of age (when Alms1 -/- mice have acquired initial signs of an AS-like phenotype, including obesity), and at 20 weeks of age (when Alms1 -/- mice have developed an advanced AS-like phenotype) (Fig

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