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doi: 10.1074/jbc.M113.462341

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Using the average bioequivalence (ABE) method, C max , AUC 0t , and AUC 0 were analyzed for individual variability after logarithmic transformation using analysis of variance (ANOVA) in a repeated crossover trial design with dosing sequence, dosing period, and formulation factors as fixed effects and formulation factors across subjects as random effects, taking into account repeated measurements of the formulation within a subject (i.e., repeated dosing of T and R), and calculating the geometric mean ratio (GMR) and its 90% confidence interval (CI)