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the one or more hepatocyte growth factor mimics has or have a general structural formula R] -R 2 -R 3 -NH-(CH 2 ) n -C-NH 2 Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s -benzyl cysteine

Journal Of Biomolecular Structure & Dynamics, 42 (10), 5015-5029

Typically administered via subcutaneous injection in experimental settings, it is now available in a breakthrough capsule formula with high oral bioavailability

In the REDEFINE 1 phase 3 trial, cagrilintide 2.4 mg monotherapy produced an average body weight reduction of 11.8% over 68 weeks