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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

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The exact pathogenesis of ferroptosis has not yet been clarified

3.3.3 Duration of Action The modified pharmacokinetic profile of SAG may support less frequent dosing regimens than unmodified GSH, potentially enabling once-daily dosing to improve consumer compliance