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While clinical trials conducted in Croatia in the early 2000s determined BPC 157 to be safe and effective in humans for the treatment of inflammatory bowel disease, there appears to be a lack of trials conducted in the U.S

However, when rat brain microsomes are used as the enzyme source, 4-OH-E 2 becomes the more predominant metabolite of E 2 over 2-OH-E 2 , with an average ratio of 4 to 1 (Fig