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Brakedal B, et al

Phase 2 dose-ranging trials followed in 20042006, and the pivotal Phase 3 trials (studies LIPO-010-05 and LIPO-010-06) ran from 2006 to 2009 , forming the efficacy basis for the November 2010 FDA approval

Weekly injections in this phase are important for: Keeping B12 stores full Watching how the patient responds and adjusting as needed Starting to move to less frequent injections Maintenance Phase: Monthly Injections After the first two phases, maintenance therapy starts with monthly injections