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THP-1 cells are usually treated with phorbol 12-myristate 13-acetate (PMA) in order to differentiate them into macrophages (Riendeau and Kornfeld, 2003)

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The activities of testicular marker enzymes such as gamma-glutamyl transferase, beta-glucuronidase, acid phosphatase, and alkaline phosphatase were increased, whereas the activities of sorbitol dehydrogenase and lactate dehydrogenase-X were decreased in animals treated with cyclophosphamide