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Petersburg Institute of Bioregulation and Gerontology as the minimal bioactive fragment of Epithalamin, a polypeptide extract of pineal origin, and the AEDG sequence has since been confirmed within that complex by mass spectrometry

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Moreover, CLOCK rhythmically acetylates the Per1 promoter and regulates circadian expression of Per1 and D-box binding PAR BZIP transcription factor ( Dbp ) (Doi et al., 2000