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However, currently available medications all cause significant adverse effects [9,13,14]

This proteomic insight paves the way for developing personalized, EV-based strategies, such as loading EVs with therapeutic proteins or engineering them for targeted drug delivery, thereby significantly advancing treatment precision and personalization

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197 With respect to the above findings, colorectal cancer pathogenesis may be significantly affected by the interplay between fungi and bacteria in the gut microbiome