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J Pharmacol Exp Ther 303:468475 Koch-Weser J (1976) Drug therapy

In contrast, regulatory approval in Western countries remains limited: in the United States, glycyrrhizin is primarily recognized as a food sweetener rather than a therapeutic agent, while in Europe, its use is largely confined to traditional medicine and flavoring

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In summary, although current studies suggest that ferroptosis plays a central regulatory role in the pathological sequence of PVLlinking hypoxiaischemia, inflammatory infiltration, and white-matter necrosisand provides a new mechanistic basis for understanding the pathway from periventricular iron accumulation to oligodendrocyte loss and motor developmental impairment, several essential gaps remain