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While significant progress has been made in optimizing encapsulation efficiency, stability, and targeted delivery, ongoing research focuses on refining stimuli-responsive behaviors (e.g., pH-, enzyme-, or redox-triggered release), improving tumor-specific accumulation through advanced surface functionalization, and conducting comprehensive long-term toxicity assessments to accelerate clinical translation [10]

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Bartsch, P., Baumgartner, R

By the time a woman reaches her early fifties, the decline has been compounding for fifteen years on top of the estrogen drop that defines the menopausal transition itself