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As a critical biological component of the upper respiratory tract (URT) mucosal barrier, URT microbiota plays a fundamental role in maintaining local immune homeostasis and reinforcing barrier defenses against environmental pathogens 95,96

The study of Meguid et al., involved 30 healthy children and 30 children affected by autism (18 males, 12 females), aged 311 years, all diagnosed with DSM-V and CARS, with no reported medical comorbidities and in good physical health

Nevertheless, metal oxide doses administrated at 1mg/kg in a single dose need proper safety profile investigation for use in clinical settings [187]

A small study from Islamabad on a clinical population of patients with megaloblastic anemia reported figures of 76% with vitamin B12 deficiency [9]