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Koren) 59 (Motherisk, 2000)

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(222) observed that a lack of GPx4 can promote the production of TGF-1, thereby exacerbating fibrosis, while upregulation of GPx4 can reverse this change

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Early in AD, APP-CTF accumulation to abnormally high levels in neuronal lysosomes more strongly inhibits the association of the V1 subcomplex with the V0 subcomplex, causing a pathological lysosomal pH rise 121 and impaired substrate hydrolysis

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