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Previously, several studies had shown that sirtuins play a critical role in regulating multiple cellular functions, such as cell growth, energy metabolism, stress resistance, inflammation, and circadian rhythm neuronal function, among others (Imai and Yoshino, 2013

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It selectively binds to MC3R and MC4R, modulating neuropeptide signaling pathways involved in hypothalamic control mechanisms

[35] Cardiometabolic disease outcomes [edit] Multiple studies have explored the association between vitamin B 12 and metabolic disease outcomes, such as obesity, insulin resistance and the development of cardiovascular disease