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6.2 Drug-induced GS status Various drugs can affect key enzymes in bilirubin metabolism, resulting in mildly elevated serum bilirubin levels (mimicking a GS state) ( Figure 6 )

Front Aging Neurosci 11:435469

ThSpositive signals were visualized under an epifluorescence microscope

It is reported that SA could reduce neuroinflammation, oxidative stress and cell apoptosis in cerebral ischemia-reperfusion injury, thereby ameliorating brain tissue damage, which may be involved in its inhibitory effect on excessive endoplasmic reticulum stress (54) indicated that SA could directly bind to the conserved cysteine residue 140 (Cys140) of IMPDH2, and further lead to IMPDH2 inactivation, thereby suppressing neuroinflammatory responses