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Factors such as age, diet, and environmental stressors can influence glutathione levels, but there are effective strategies to enhance its production, including consuming sulfur-rich foods, increasing vitamin C intake, and regular exercise

Replicative stress induced by hypoxia activates ATR, thereby enhancing the translation of HIF-1 and augmenting its DNA-binding ability [250]

This improves the bioavailability of the nutrients which means more nutrients for the cells to utilise

21 Among these precursors, NAM could be recycled from NAD + consumption reactions, including both NAD + -dependent deacylation and ADP-ribosylation, into NMN by NAMPT, which catalyzes the rate-limiting reaction in the salvage pathway