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For example, the polynucleotide may be partially phosphorothioate-linked, e.g., phosphorothioate linkages may alternate with phosphodiester linkages

The researchers also discovered nanoparticles produce more potent and balanced serum IgG antibodies than the corresponding soluble protein mixture, and the immune responses are sustained for at least four months after the immunization

& Lee, S.-W

When ER stress is excessive or prolonged beyond the adaptive threshold, UPR signaling can shift from cytoprotective to pro-apoptotic outcomes, frequently through crosstalk with mitochondrial death pathways