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Lab animals have been bred or engineered that carry versions of mitochondrial DNA that increase free-radical production (Yardeni et al., 2019)

Additionally, the complexity of these systems may increase the risk of formulation instability and regulatory challenges

However, it would be interesting to assess CD38 expression in T cells from symptomatic familial AD individuals, and whether CD38 could also serve as an early diagnostic marker in sporadic AD, which accounts for 9095% of AD cases 1

188 Conversely, asprosin, interleukin-6 (IL-6), TNF-, and IL-12p70, which are predominantly secreted by visceral adipose tissue, 189 impair insulin signaling in muscle and liver and drive non-alcoholic fatty liver disease 190 via pro-inflammatory mechanisms