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IS is a prevalent condition among the elderly, but there has been a noticeable increase in its occurrence among younger individuals in recent years

2.4.1 CSF-mediated signaling pathway In recent years, CSF1/CSF1R axis has attracted more attention in clinical applications

To increase glutathione biosynthesis through enhancement of the l-Ser biosynthetic pathway, recombinant GCI strains overexpressing each gene ( SER2, SER1, SER3 , and SER33 ) and simultaneously overexpressing strains ( SER3 / SER33 and SER2 / SER1 / SER3 / SER33 ) were constructed, as well as a vector control GCI strain (Table 2)