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While the exact origin of inflammation isnt known, researchers have a good idea of three contributing factors : genetics, environmental triggers, and loss of immune privilege in the follicle

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Some breeds may carry a gene for hereditary cobalamin deficiency, but the specific gene has not been identified

Resveratrol has a similar action to quercetin, but a different chemical structure, resveratrol activates antioxidant enzymes and decreases the secretion of superoxide anion, hydroxyl radical, and inflammatory cytokines by modulating the NRF2/kelch-like ECH-associated protein 1 signaling pathway and AMPK expression