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Many studies, including those reviewed below, have reported results consistent with a neuroinflammatory process [e.g., ( Inflammation Neurocircuitry Many patients with ME/CFS report having experienced a viral or bacterial infection directly prior to the onset of their illness [e.g., ( When an inflammatory response occurs in the periphery, the brain is alerted to the presence of inflammation-associated molecules such as proinflammatory cytokines circulating in blood

siRNA function in RNAi: A chemical modification analysis