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While still highly significant versus baseline, the high-dose group actually produced fewer new hairs than the low-dose group consistent with the biphasic dose-response seen in the 2007 Pyo laboratory study where higher copper peptide concentrations inhibited rather than stimulated growth

The most severe conditions associated with defects in the axis may cause a loss of adult height of approximately 1/3 and may cause severe developmental and neurological deficits and compromise pubertal maturation and fertility