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This might explain the common x axis intercept in LineweaverBurk plots 11,17,18 , which resemble a non-competitive inhibition pattern with identical dissociation constants for the inhibitor and substrate 52

12-weeks of caloric restriction diet improves cortical cerebral blood flow in healthy middle-age adults

On-target efficacy of a HIF-2alpha antagonist in preclinical kidney cancer models

However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD