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2.6 An integrated framework for UC pathogenesis Overall, the pathogenesis of UC reflects a complex interplay among multiple etiologic factors rather than a single determinant

doi: 10.1016/j.exer.2016.12.008 173 VogtASArsiwalaTMohsenMVogelMManolovaVBachmannMF

Sarno, 2020) (e.g., in response to acute stress) (Huang et al., 2003), increase vascular permeability and disrupt the BBB (Theoharides and Konstantinidou, 2007)