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Clin Immunol 2011;140:268275.ArticlePubMedPMC 71

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Symptoms of a Herxheimer reaction include a sudden, intense exacerbation of baseline symptoms: severe brain fog, debilitating fatigue, migrating joint pain, flu-like body aches, headaches, and heightened anxiety

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In laboratory settings, testing these specific compounds together provides a robust framework to monitor fibroblast migration alongside cytokine downregulation

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