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However, the biocompatibility and biosafety of nanostructures are an issue and therefore, their clinical application requires highlighting their long-term safety

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This is supported at least in part at the biochemical level: the Km of L-cysteinyl-tRNA synthetase towards cysteine, which directs cysteine to translational machinery, is less than one tenth of that for other enzymes of cysteine metabolism such as GCS or cysteine dioxygenase 22