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For instance, Arem et al

Indoxyl sulfate activates NF-B signaling pathway, leading to increased intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) expression in endothelial cells (Tumur et al., 2010)

114 The PAD guidelines state that a program of supervised exercise training is recommended as an initial treatment modality for patients with claudication (class I, level of evidence A) and that supervised exercise training should be performed for a minimum of 30 to 45 minutes, in sessions performed at least 3 times per week for a minimum of 12 weeks (class I, level of evidence A)

in Endocrine Reviews : Even a small decrease in cellular ATP concentration results in a major reduction in the transport of T4 (and rT3) but only slightly affects T3 uptake. This makes it inappropriate to use T4-only preparations when treating any condition associated with reduced mitochondrial function or ATP production, Thus, it is not surprising that T3 has been shown to be superior in such patient populations