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Also, immunomodulatory properties influencing type 2 responses have been described for a helminth GST from Schistosoma that reduces intestinal inflammation through eosinophil-dependent modulation of pathological Th1 responses (49)

One approach involves chemical modifications, such as phosphorothioation, 2-O-methylation, and glycosylation, which enhance the stability of nucleic acids and reduce their degradation by nucleases