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Appetite Suppression (Central Nervous System) GLP-1 RAs can cross the blood-brain barrier or act on circumventricular organs to target specific brain regions, including the hypothalamus, hindbrain, and mesolimbic reward system (Zheng et al., 2024)

The preprotein translocases that reside on the mitochondrial membranes not only function during organelle biogenesis to deliver newly synthesized proteins to their final mitochondrial destination but also cooperate with numerous other mitochondrial protein complexes that perform a wide range of functions

These are predominantly mild to moderate and transient