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Endocrine 73(3):609616

Upon binding, ivermectin causes a prolonged phase of chloride ion influx, resulting in hyperpolarization, neuronal firing inhibition, paralysis, and ultimately, death of the parasite ( -aminobutyric acid (GABA)-gated chloride channel at higher concentrations, to further inhibit nervous system dysfunction in susceptible parasites (78)

As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy

doi: 10.1038/sj.jhh.1001416 Vanderah TW (2024): Cholinoceptor-Blocking Drugs