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Step 4: 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin- 1 -yl)pyridin-2-yl-3 ,4,6- d3)amino)-7H-pyrrolo| 2,3-d |pyrimidine-6-carboxamide According to the procedure described for Step 4 in Example 2, Example S was prepared from /erf-butyl 4-(6-((7-cyclopentyl-6-(diniethylcarbamoyl)-7H-pyrrolo|2,3- d|pyrimidin-2-yl)amino)pyridin-3-yl-2,4,5-d3)pipera/ine-l -carboxylate and HC1 solution

Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations