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The presented data are representative of four independent experiments

It was demonstrated that the interaction between NPs and the mucus can be also decreased by modulating the particle surface charge, which needs to be as neutral as possible (with -potential values in the 10 mV range)

Phase 1 study of glutaminase (Gls) inhibitor cb-839 combined with either everolimus (E) or cabozantinib (Cabo) in patients (Pts) with clear cell (Cc) and papillary (Pap) metastatic renal cell cancer (Mrcc)