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Description

TAPS PP3408

Although the OXPHOS pathway is more energy efficient, since it generates 36 moles of ATP, cancer cells rely on glycolysis, which produces less ATP faster: 2 molecules of ATP are produced from 1 molecule of glucose

Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells