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To assess the functional status of mitochondria after BPM31510 treatment in these cell lines, mitochondrial membrane potential () was assessed using the lipophilic cation fluorescent dye TMRE, which is sequestered in active (polarized) but not in inactive (depolarized) mitochondria 15

Chen Z, Ho IL, Liu J, Soeung M, Yen EY, Sainani S, Dyke CA, Shah R, Kwon HJ, Han G, Yan X, Zhang S, Srinivasan S, Rose JL, Citron F, Jiang S, Chang Q, Feng N, Genovese G, Gao S, Yao W, Wang L , Wang H, Ying H, Viale A, Draetta GF

Exploiting the PI3K/AKT pathway for cancer drug discovery

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