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10.3389/fcvm.2022.838657 19

CMS is committed to looking holistically at the concerns raised by the commenter across settings of care and will consider how to address for future rulemaking or guidance, and we thank the commenter for continuing to share firsthand experiences

The fact that high levels of peripheral markers of oxidativeinflammatory stress were detected in individuals with MCI lead us to believe that oxidative stress and inflammation are early events in the pathogenesis of AD, and that they precede A deposits and the onset of AD symptoms, which has been shown in experimental models of AD (Ferretti et al., 2012

It is also essential to prioritize overall skin health, which includes a balanced diet, sun protection, and a comprehensive skincare routine