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NICE-aligned management typically involves: Addressing modifiable risk factors (smoking cessation, weight loss, increased physical activity, alcohol reduction) Optimising management of underlying conditions (diabetes, hypertension, depression) Trial of PDE5 inhibitor therapy Referral to specialist services (urology/andrology) if first-line treatments fail or where structural/neurological/endocrine causes are suspected Consideration of psychosexual therapy where appropriate Men should be reassured that ED is a medical condition with effective treatments, and seeking help through proper channels ensures safety, appropriate investigation of underlying causes, and access to evidence-based therapies

On average, individuals lost about 15% of their body weight over 68 weeks of treatment

Tretinoin is the strongest of the prescription retinoids, so layering it with retinol is redundant

doi: 10.1016/s0002-9378(16)32697-7 139 NovyMJWalshSW