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2 Materials and methods 2.1 Experimental mouse models In the acute SCI model, adult male C57BL/6N mice (1012 weeks, male, Nihon SLC, Shizuoka, Japan) were subjected to contusion injury at T9T10 using an Infinite Horizon Impactor (60 kdyn) or sham-operated by laminectomy only, as described previously (Figure 1A) (Scheff et al., 2003)

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Median IC 50 values for the field isolates for the four drugs were considered by year (Table 1)

While no injuries or deaths have been reported so far, the company said it will replace the ventilator motor assembly for suspected affected products.