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Since the low concentrations of cobalamin in our subjects were found as part of a screening program, in the absence of specific clinical symptoms, we assume that the subjects were at an early stage of negative cobalamin balance [16]

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

This leads to reduced oxidative stress and stimulates hair growth by dermal papilla cells

For long-term storage, aliquot and freeze at 20 C or below