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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

Vitamin B12 (cobalamin) is essential for: Energy production Red blood cell formation Brain and nerve function Mood regulation Healthy sleep cycles The problem

In some cases, the total value may appear normal even though your cells have a functional deficiency

B12 also plays a role in maintaining your nerve cells, helping them work properly and keeping your brain sharp