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longum with selenium supplementation could enhance cognitive and metabolic profiles compared to selenium only or placebo control groups [131]

Association between B vitamins supplementation and risk of cardiovascular outcomes: A cumulative meta-analysis of randomized controlled trials

2017 Apr 26;8(2):15362

HIFs (1 and 2) operate via their oxygen-dependent subunits, which are modified by oxygen-requiring prolyl hydroxylases and directed to degradation in proteasome by pVHL tumor suppressor protein under normoxic conditions, while they escape degradation and are stabilized and activated in hypoxia