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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines

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Despite the negative results observed, since 2005 to date, more than a dozen of AAAs entered in clinical trials, but most of these trials terminated unsuccessfully and with no FDA approval

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