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The liver is its primary site of manufacturing

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To mimic ischaemia, some hearts were removed and then incubated ex vivo at 37 C for 30 min under ischaemic conditions, which are known to replicate the metabolic changes that occur during ischaemia in vivo 53

Exposure to light can damage B12, so store B12 supplements and fortified foods in a dark, cool place, preferably a refrigerator