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Description

10.1289/ehp.9932 173 PrzedborskiS.Jackson-LewisV.NainiA

This modification strengthens the interaction of PIK3C3/VPS34 with BECN1, ATG14, and UVRAG, enhances its lipid kinase activity, and promotes both macroautophagy and endolysosomal degradation

It is thought that the rate of this reaction is limiting in certain conditions like in the elderly, under certain disease states and in premature infants